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Sibutramine Systematic sibutramine wikipedia the free encyclopedia name 1-- N,N,3- trimethylbutan- 1-amine Identifiers CAS number 106650-56-0 ATC code A08AA10 PubChem 5210
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DrugBank APRD00456 ChemSpider 5021 Chemical data sibatramine Formula C17H26ClN Mol. mass 279. 85 g/mol Pharmacokinetic data
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Bioavailability Absorption 77%, considerable first-pass metabolism Metabolism Hepatic (CYP3A4-mediated) sibutramine wikipedia the free encyclopedia ibutramine life sibutramine approx. 1 hour Metabolite achat de sibutramine
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hours Metabolite 2: 16 hours Excretion Biliary (sibutramine and
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renal
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metabolites) Therapeutic considerations Pregnancy cat.
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C(AU) C(US) No human data sibutramine wikipedia the free inconclusive evidence
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teratogenic potential in animal studies Legal status Schedule IV(US)
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Routes Oral Sibutramine (trade
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Meridia in the 25 sibutramine and Canada, Ectiva in South Africa, Reductil in Europe and most other countries), siutramine as sibutramine hydrochloride monohydrate, is an orally administered agent for the treatment of obesity, as an appetite suppressant.
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is a centrally-acting serotonin-norepinephrine reuptake inhibitor structurally related to amphetamines, although its mechanism of action is sibutramine still manufactered distinct. Sibutramine is manufactured by Abbott Laboratories. It is classified as a Schedule IV sibutramine hydrochloride monhydrate substance in the United States, despite having virtually no potential for abuse (due to its lack of appreciable dopaminergic effects). pharmacy online us reductil sibutramine is likely that the compound's use as an sibutramine bulimia is sibutramine compare prices sole reason is it classified as a controlled drug, as "overprescription" of anorectics (as a
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in the mid-20th century resulted in a number of cases of abuse or addiction. Contents 1 Pharmacokinetics 2 sibutramine patient information 3 Contraindications 4 Side effects 5 Interactions
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Dosage sibutramine snorting Safety concerns sibutramine compare prices References 9 External links // Pharmacokinetics sibutranine
appetite suppression drug sibutramine meridia phentermine
well absorbed from the GI tract (77%), but undergoes considerable first-pass metabolism, reducing its bioavailability. The drug itself reaches its sibutramine hydochloride plasma level after 1 hour and has also a half-life of 1 hour. Sibutramine is metabolized by cytochrome P450 isozyme CYP3A4 into two pharmacologically-active buy sibutramine mg and secondary amines (called active metabolites 1 and 2) with half-lives of 14 and 16 hours, respectively. Peak plasma concentrations of active metabolites 1 and 2 are reached after three to four hours. The following metabolic pathway mainly results in two inactive conjugated and
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metabolites (called metabolites 5 meridia patient information instructions sibutramine 6). Metabolites 5 and sibutramine bulimia are mainly excreted in
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urine. Pharmacodynamics Sibutramine is a what is sibutramine reuptake inhibitor that reduces the reuptake of serotonin (by 53%), norepinephrine 2 metformin obesity sibutramine treatment type
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and dopamine (by 16%), chemical structure of sibutramine increasing whay is sibutramine levels of these substances in synaptic clefts buy sibutramine online helping enhance satiety; the serotonergic action, in particular, is to influence appetite. Older anorectic agents sibutramine hydrochloride monohydrate sibutrramine amphetamine and fenfluramine force the release of these neurotransmitters rather than affecting their reuptake. Despite having a mechanism of action similar to tricyclic antidepressants, sibutramine has failed to demonstrate antidepressant properties in animal studies. It was approved by the
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Contraindications Sibutramine is contraindicated in: Psychiatric conditions as bulimia nervosa, anorexia nervosa, serious depression or preexisting mania Patients with a history of or a predisposition to drug or alcohol abuse Hypersensitivity to the drug Patients below 18 years of age Concomitant treatment with a MAO inhibitor, antidepressant or other centrally active drugs, particularly other anoretics Hypertension that is not sufficiently controlled (caution in controlled hypertension) Existing pulmonary hypertension Existing damage on heart valves, coronary heart disease, congestive heart failure, sibutramie arrhythmias, previous myocardial sibutramine capsules acheter de la sibutramine or transient ischemic attack (TIA) Hyperthyroidism (overactive thyroid gland) Closed angle glaucoma Seizure disorders Enlargement of the prostate gland with
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retention (relative C. I. ) Pheochromocytoma Pregnant and lactating women (relative C. I. ) Side effects Frequently encountered side effects are: dry mouth, paradoxically afvallen sibutramine fluoxitine appetite, nausea, strange taste in the mouth, sibutramine meridia sibutraamine constipation, trouble sleeping, dizziness, drowsiness, menstrual cramps/pain, sbutramne flushing, or joint/muscle pain. Sibutramine can substantially sibbutramine blood pressure and pulse in
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patients. Therefore all patients treated with sibutramine should have regular monitoring of blood pressure and pulse. The following side effects are infrequent but serious and require immediate medical attention: cardiac arrhythmias, paresthesia, mental/mood changes (e. g. , excitement, restlessness, is sibutramine still manufactered depression, rare thoughts of suicide). Symptoms that require urgent medical attention are
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problems urinating, abnormal bruising or bleeding, melena, hematemesis, sibutramine vs phentermine fever and rigors, chest pain, hemiplegia, abnormal vision, dyspnea and edema. Currently, no case of pulmonary hypertension has
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